ANGIOTENSIN-II AND FLUID INGESTION IN OLD RATS

被引：23

作者：

SILVER, AJ ^{[1
]}

MORLEY, JE ^{[1
]}

ISHIMARUTSENG, TV ^{[1
]}

MORLEY, PMK ^{[1
]}

机构：

[1] ST LOUIS DEPT VET AFFAIRS,CTR GERIATR RES EDUC & CLIN,ST LOUIS,MO 63104

来源：

NEUROBIOLOGY OF AGING | 1993年 / 14卷 / 06期

关键词：

AGING; FLUID INGESTION; ANGIOTENSIN II;

D O I：

10.1016/0197-4580(93)90033-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Fluid ingestion was studied in Fischer 344/Brown Norway F1 rats aged 3; 12, 20, and 24 months of age. There was an age-related decrease in fluid ingestion when fluid intake was measured over 24 h. After water deprivation, 24- and 20-month-old rats drank less than 3- and 12-month-old rats. Twelve, 20-, and 24-month-old rats had less fluid intake associated with food deprivation than did 3-month-old rats. Three month old rats drank more fluid after angiotensin II than did 12-, 20-, and 24-month-old rats when expressed as fluid intake per kg body weight. These studies confirm that the rat is a reasonable model to study age-related hypodipsia.

引用

页码：519 / 522

页数：4

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