STUDY OF 3-ALPHA,20-BETA-HYDROXYSTEROID DEHYDROGENASE WITH AN ENZYME-GENERATED AFFINITY ALKYLATOR - DUAL ENZYME-ACTIVITY AT A SINGLE ACTIVE-SITE

被引:35
作者
STRICKLER, RC [1 ]
COVEY, DF [1 ]
TOBIAS, B [1 ]
机构
[1] WASHINGTON UNIV,DEPT PHARMACOL,ST LOUIS,MO 63110
关键词
D O I
10.1021/bi00563a002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:4950 / 4954
页数:5
相关论文
共 15 条
[1]   REACTION MECHANISM AND STEREOSPECIFICITY OF 20 BETA-HYDROXYSTEROID DEHYDROGENASE [J].
BETZ, G ;
WARREN, JC .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 128 (03) :745-&
[2]  
BETZ G, 1968, THESIS U KANSAS LAWR, P63
[3]   MOLECULAR-WEIGHT AND SUBSTRATE-SPECIFICITY OF 20 BETA-HYDROXYSTEROID DEHYDROGENASE FROM STREPTOMYCES-HYDROGENANS [J].
BLOMQUIST, CH .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1973, 159 (02) :590-595
[4]   SYNTHESIS OF 17-BETA-[(1S)-1-HYDROXY-2-PROPYNYL]- AND 17-BETA-[(1R)-1-HYDROXY-2-PROPYNYL]ANDROST-4-EN-3-ONE - POTENTIAL SUICIDE SUBSTRATES OF 2O-ALPHA-HYDROXYSTEROID AND 2O-BETA-HYDROXYSTEROID DEHYDROGENASES [J].
COVEY, DF .
STEROIDS, 1979, 34 (02) :199-206
[5]   COMPARISON OF 3-ALPHA-HYDROXYSTEROID AND 20-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITIES OF CORTISONE REDUCTASE OF STREPTOMYCES-HYDROGENANS [J].
EDWARDS, CAF ;
ORR, JC .
BIOCHEMISTRY, 1978, 17 (21) :4370-4376
[6]   RELATIONSHIPS BETWEEN 3ALPHA- AND 20BETA-HYDROXYSTEROID - NAD-OXIDOREDUCTASE ACTIVITY OF A CRYSTALLINE-ENZYME PREPARATION [J].
GIBB, W ;
JEFFERY, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1971, 23 (02) :336-&
[7]   3-HYDROXY STEROID DEHYDROGENASE-ACTIVITIES OF CORTISONE REDUCTASE [J].
GIBB, W ;
JEFFERY, J .
BIOCHEMICAL JOURNAL, 1973, 135 (04) :881-888
[8]   STERIC, CHIRAL AND CONFORMATIONAL ASPECTS OF 3-HYDROXYSTEROID AND 20-HYDROXYSTEROID DEHYDROGENASE-ACTIVITIES OF CORTISONE REDUCTASE PREPARATIONS [J].
GIBB, W ;
JEFFERY, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1972, 268 (01) :13-&
[9]  
KITZ R, 1962, J BIOL CHEM, V237, P3245
[10]   3 ALPHA-HYDROXYSTEROID - NAD OXIDOREDUCTASE ACTIVITY IN CRYSTALLINE PREPARATIONS OF 20 BETA-HYDROXYSTEROID - NAD OXIDOREDUCTASE [J].
POCKLINGTON, T ;
JEFFERY, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1968, 7 (01) :63-+