CONTROLLED BIOSYNTHESIS OF NEOVIRIDOGRISEINS, NEW HOMOLOGS OF VIRIDOGRISEIN .2. PRODUCTION, BIOLOGICAL PROPERTIES AND STRUCTURE OF NEOVIRIDOGRISEIN-II

被引：18

作者：

OKUMURA, Y

TAKEI, T

SAKAMOTO, M

ISHIKURA, T

FUKAGAWA, Y

机构：

[1] Central Research Laboratories, Sanraku-Ocean Co.,Ltd., Fujisawa-shi 251

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 06期

关键词：

D O I：

10.7164/antibiotics.32.584

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Our isolate of Streptomyces griseoviridus, which produced three minor factors in addition to viridogrisein and griseoviridin, was more sensitive to the addition of L-proline than the type culture of Streptomyces griseoviridus (NRRL2427). Yield improvement of these minor factors was attempted by the so-called controlled biosynthesis with L-proline. Addition of L-proline increased the production of neoviridogrisein II in which allo-hydroxy-D-proline in viridogrisein was replaced by D-proline. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：584 / 592

页数：9

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