RELATIONSHIP BETWEEN FETAL HYPOXIA AND ENDOTHELIN-1 IN FETAL CIRCULATION

被引:24
作者
HASHIGUCHI, K
TAKAGI, K [1 ]
NAKABAYASHI, M
TAKEDA, Y
SAKAMOTO, S
NARUSE, M
NARUSE, K
DEMURA, H
机构
[1] TOKYO WOMENS MED COLL,CTR MATERNAL & PERINATAL,DEPT OBSTET & GYNECOL,SHINJUKU KU,TOKYO 162,JAPAN
[2] TOKYO WOMENS MED COLL,INST CLIN ENDOCRINOL,DEPT MED,TOKYO 162,JAPAN
关键词
ENDOTHELIN; FETUS; HYPOXIA; UMBILICAL VENOUS BLOOD PH; PREGNANCY;
D O I
10.1097/00005344-199100177-00145
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The role of endothelin-1 (ET-1), a potent vasoconstrictor peptide secreted by endothelial cells, in fetal circulation was investigated in relation to fetal hypoxia. Umbilical venous blood was obtained from 23 subjects who delivered between 36 and 41 weeks of gestation. In all cases, pH of umbilical venous blood was measured immediately after the delivery of placenta. ET-1 was extracted from the umbilical venous plasma by an Amprep C2 column and determined by a specific radioimmunoassay. Immunoreactive ET levels in the umbilical cord plasma (pg/ml, mean +/- SEM) from subjects with umbilical venous blood pH levels below 7.30 (n = 9) were 12.53 +/- 2.03, significantly higher than those with pH levels above 7.30 (6.44 +/- 1.11, n = 14). These results indicate that ET-1 in the fetal circulation may be involved in the regulation of the circulation in response to changes in acid-base balance related to fetal hypoxia.
引用
收藏
页码:S509 / S510
页数:2
相关论文
共 7 条
[1]   HYPOXIA INCREASES ENDOTHELIN RELEASE IN BOVINE ENDOTHELIAL-CELLS IN CULTURE, BUT EPINEPHRINE, NOREPINEPHRINE, SEROTONIN, HISTAMINE AND ANGIOTENSIN-II DO NOT [J].
HIEDA, HS ;
GOMEZSANCHEZ, CE .
LIFE SCIENCES, 1990, 47 (03) :247-251
[2]   EFFECTS OF MODERATE HYPOXIA, HYPERCAPNIA AND ACIDOSIS ON HEMODYNAMIC-CHANGES INDUCED BY ENDOTHELIN-1 IN THE PITHED RAT [J].
MACLEAN, MR ;
RANDALL, MD ;
HILEY, CR .
BRITISH JOURNAL OF PHARMACOLOGY, 1989, 98 (03) :1055-1065
[3]   IMMUNOREACTIVE ENDOTHELIN CONCENTRATIONS IN MATERNAL AND FETAL BLOOD [J].
NAKAMURA, T ;
KASAI, K ;
KONUMA, S ;
EMOTO, T ;
BANBA, N ;
ISHIKAWA, M ;
SHIMODA, S .
LIFE SCIENCES, 1990, 46 (15) :1045-1050
[4]   RADIOIMMUNOASSAY FOR ENDOTHELIN AND IMMUNOREACTIVE ENDOTHELIN IN CULTURE-MEDIUM OF BOVINE ENDOTHELIAL-CELLS [J].
NARUSE, M ;
NARUSE, K ;
KURIMOTO, F ;
HORIUCHI, J ;
TSUCHIYA, K ;
KAWANA, M ;
KATO, Y ;
ZENG, ZP ;
SAKURAI, H ;
DEMURA, H ;
SHIZUME, K .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (02) :662-668
[5]   EVIDENCE FOR ENDOTHELIN-1 RELEASE FROM RESISTANCE VESSELS OF RATS IN RESPONSE TO HYPOXIA [J].
RAKUGI, H ;
TABUCHI, Y ;
NAKAMARU, M ;
NAGANO, M ;
HIGASHIMORI, K ;
MIKAMI, H ;
OGIHARA, T ;
SUZUKI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (03) :973-977
[6]  
WILKES BM, 1990, AM J PHYSIOL, V258, P864
[7]   A NOVEL POTENT VASOCONSTRICTOR PEPTIDE PRODUCED BY VASCULAR ENDOTHELIAL-CELLS [J].
YANAGISAWA, M ;
KURIHARA, H ;
KIMURA, S ;
TOMOBE, Y ;
KOBAYASHI, M ;
MITSUI, Y ;
YAZAKI, Y ;
GOTO, K ;
MASAKI, T .
NATURE, 1988, 332 (6163) :411-415