The analysis of neural recognition molecules: benefits and vicissitudes of functional knock-outs using antibodies and gene ablation

被引：14

作者：

Schachner, Melitta ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Dept Neurobiol, CH-8093 Zurich, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 05期

关键词：

D O I：

10.1016/0955-0674(93)90026-M

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Altering or removing neural recognition molecules by blocking antibodies or genetic deletion has led to a flurry of predictions concerning their function. Each experimental approach has advantages and disadvantages that have to be considered when interpreting the resulting phenotypes.

引用

页码：786 / 790

页数：5

共 30 条

[1] NEURAL CELL-ADHESION MOLECULES MODULATE TYROSINE PHOSPHORYLATION OF TUBULIN IN NERVE GROWTH CONE MEMBRANES
ATASHI, JR
KLINZ, SG
INGRAHAM, CA
MATTEN, WT
SCHACHNER, M
MANESS, PF
[J]. NEURON, 1992, 8 (05) : 831 - 842
[2] DYNAMICS OF ANTIGENIC MEMBRANE SITES RELATING TO CELL AGGREGATION IN DICTYOSTELIUM-DISCOIDEUM
BEUG, H
KATZ, FE
GERISCH, G
[J]. JOURNAL OF CELL BIOLOGY, 1973, 56 (03) : 647 - 658
[3] MOLECULAR MECHANISMS OF AXON GROWTH AND GUIDANCE
BIXBY, JL
HARRIS, WA
[J]. ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 : 117 - 159
[4] NORMAL DEVELOPMENT AND BEHAVIOR OF MICE LACKING THE NEURONAL CELL-SURFACE PRP PROTEIN
BUELER, H
FISCHER, M
LANG, Y
BLUETHMANN, H
LIPP, HP
DEARMOND, SJ
PRUSINER, SB
AGUET, M
WEISSMANN, C
[J]. NATURE, 1992, 356 (6370) : 577 - 582
[5] Doherty P, 1992, Curr Opin Neurobiol, V2, P595, DOI 10.1016/0959-4388(92)90024-F
[6] NEURONAL PROCESS OUTGROWTH OF HUMAN SENSORY NEURONS ON MONOLAYERS OF CELLS TRANSFECTED WITH CDNAS FOR 5 HUMAN N-CAM ISOFORMS
DOHERTY, P
BARTON, CH
DICKSON, G
SEATON, P
ROWETT, LH
MOORE, SE
GOWER, HJ
WALSH, FS
[J]. JOURNAL OF CELL BIOLOGY, 1989, 109 (02) : 789 - 798
[7] CELL-ADHESION MOLECULES - IMPLICATIONS FOR A MOLECULAR HISTOLOGY
EDELMAN, GM
CROSSIN, KL
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 : 155 - 190
[8] DIFFERENT EXTRACELLULAR DOMAINS OF THE NEURAL CELL-ADHESION MOLECULE (N-CAM) ARE INVOLVED IN DIFFERENT FUNCTIONS
FREI, T
HALBACH, FV
WILLE, W
SCHACHNER, M
[J]. JOURNAL OF CELL BIOLOGY, 1992, 118 (01) : 177 - 194
[9] MOUSE P(0) GENE DISRUPTION LEADS TO HYPOMYELINATION, ABNORMAL EXPRESSION OF RECOGNITION MOLECULES, AND DEGENERATION OF MYELIN AND AXONS
GIESE, KP
MARTINI, R
LEMKE, G
SORIANO, P
SCHACHNER, M
[J]. CELL, 1992, 71 (04) : 565 - 576
[10] TIGHT CONTROL OF GENE-EXPRESSION IN MAMMALIAN-CELLS BY TETRACYCLINE-RESPONSIVE PROMOTERS
GOSSEN, M
BUJARD, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) : 5547 - 5551

← 1 2 3 →