DIBUTYRYL-CYCLIC-AMP AND FORSKOLIN INHIBIT PHOSPHATIDYLINOSITOL HYDROLYSIS CA-2+ INFLUX AND CONTRACTION IN VASCULAR SMOOTH-MUSCLE

被引：25

作者：

HEE, YA

SEUNG, EK

KI, CC

KARAKI, H

机构：

[1] UNIV TOKYO, FAC AGR, DEPT VET PHARMACOL, TOKYO 113, JAPAN

[2] CHUNGBUK NATL UNIV, COLL MED, DEPT PHARMACOL, CHONGJU 360763, SOUTH KOREA

[3] JOONGANG UNIV, COLL PHARM, DEPT BIOCHEM, SEOUL 156756, SOUTH KOREA

[4] GYEONGSANG NATL UNIV, COLL MED, DEPT PHARMACOL, CHINJU 660280, SOUTH KOREA

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 59卷 / 02期

关键词：

CYCLIC AMP; PHOSPHATIDYLINOSITOL TURNOVER; VASODILATION;

D O I：

10.1254/jjp.59.263

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dibutyryl cyclic AMP and forskolin inhibited the contraction induced by norepinephrine (NE) more strongly than the high K+-induced contraction in isolated rat aorta. These inhibitors inhibited the Ca-45(2+) influx stimulated by NE but not that by high K+, and they inhibited NE-induced inositol monophosphate accumulation. These results suggest that cAMP inhibits NE-induced contraction, at least partly, by inhibiting the a-adrenoceptor-mediated signal transduction and high K+-induced contraction by decreasing Ca2+ sensitivity but not Ca2+ influx.

引用

页码：263 / 265

页数：3

共 10 条

[1] BIOCHEMICAL AND FUNCTIONAL INTERACTIONS BETWEEN THE INOSITOL 1,4,5-TRISPHOSPHATE-CA2+ AND CYCLIC-AMP SIGNALING SYSTEMS IN SMOOTH-MUSCLE [J].