SYNTHESIS OF A C-15 C-27 SEGMENT OF VENTURICIDINE

被引：12

作者：

HOFFMANN, RW

ROLLE, U

机构：

[1] Philipps-Universität Marburg, Fachbereich Chemie D -

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(00)76958-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-15/C-27 segment of venturicidine contains a 1,3,5,n-anti-methylated alkyl chain, which resembles syndiotactic polypropylene and should therefore favor an extended conformation. A synthetic scheme is presented, by which such structures are generated in a cycle of four steps per three stereogenic centers. This allowed the synthesis of the above mentioned venturicidine fragment in 15 steps from propionaldehyde.

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页码：4751 / 4754

页数：4

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