PARANEOPLASTIC INTESTINAL PSEUDOOBSTRUCTION ASSOCIATED WITH HIGH TITERS OF HU AUTOANTIBODIES

被引：42

作者：

CONDOM, E

VIDAL, A

ROTA, R

GRAUS, F

DALMAU, J

FERRER, I

机构：

[1] HOSP PRINCIPES ESPANA,SERV ANAT PATOL,UNIDAD NEUROPATOL,E-08907 LHOSPITALET LLOBR,SPAIN

[2] HOSP PRINCIPES ESPANA,SERV GASTROENTEROL,LHOSPITALET LLOBR,SPAIN

[3] HOSP CLIN BARCELONA,SERV NEUROL,E-08036 BARCELONA,SPAIN

[4] MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,NEW YORK,NY 10021

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1993年 / 423卷 / 06期

关键词：

SMALL-CELL LUNG CANCER; PARANEOPLASTIC ENCEPHALOMYELITIS/SENSORY NEURONOPATHY; PSEUDOOBSTRUCTION; VISCERAL NEURONOPATHY; HU ANTIGEN/ANTIBODY;

D O I：

10.1007/BF01606543

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudoobstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.

引用

页码：507 / 511

页数：5

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