GROWTH-HORMONE SECRETAGOGUES - CLINICAL-EXPERIENCE AND THERAPEUTIC POTENTIAL

被引：39

作者：

LARON, Z ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER SCH MED,IRENE & NICHOLAS MARSH CHAIR ENDOCRINOL & DIABET,IL-69978 TEL AVIV,ISRAEL

来源：

DRUGS | 1995年 / 50卷 / 04期

关键词：

D O I：

10.2165/00003495-199550040-00002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, several biosynthetic hexa- and heptapeptides, as well as non-peptide bezolactam derivatives, have been found to be potent growth hormone (GH) secretagogues. They act synergistically with GH-releasing hormone (GHRH) but via different receptors, and are GHRH dependent. All are active when administered intravenously, orally or subcutaneously. Short and long term experience in adults and children has proven that these drugs evoke the metabolic changes induced by GH and insulin-like growth factor-1 (IGF-1), including acceleration of growth velocity in children. With the exception of a partial downregulation phenomenon, no adverse effects have been reported so far. This new class of hormone-like drugs acting as GH secretagogues may have immense clinical potential.

引用

页码：595 / 601

页数：7

共 45 条

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