OPTICAL RESOLUTION OF RACEMIC PANTOLACTONE WITH A NOVEL FUNGAL ENZYME, LACTONOHYDROLASE

被引：43

作者：

KATAOKA, M ^{[1
]}

SHIMIZU, K ^{[1
]}

SAKAMOTO, K ^{[1
]}

YAMADA, H ^{[1
]}

SHIMIZU, S ^{[1
]}

机构：

[1] KYOTO UNIV,FAC AGR,DEPT AGR CHEM,SAKYO KU,KYOTO 60601,JAPAN

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 1995年 / 43卷 / 06期

关键词：

D O I：

10.1007/BF00166911

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel enzymatic process for the optical resolution of racemic pantolactone through the stereospecific hydrolysis of D-pantolactone by lactonohydrolase of Fusarium oxysporum is described. F, oxysporum cells were found to catalyze the stereoselective hydrolysis of the D-enantiomer of racemic pantolactone. With 135 g/l DL-pantolactone as the substrate, 41% was hydrolyzed and pantoic acid with an optical purity of 90% enantiomeric excess (for D-pantoic acid) was formed.

引用

页码：974 / 977

页数：4

共 7 条

[1]

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