XANTHINE-OXIDASE INHIBITORS FROM THE LEAVES OF ALSOPHILA-SPINULOSA (HOOK) TRYON

被引:84
作者
CHIANG, HC [1 ]
LO, YJ [1 ]
LU, FJ [1 ]
机构
[1] NATL TAIWAN UNIV,COLL MED,DEPT BIOCHEM,TAIPEI 10764,TAIWAN
来源
JOURNAL OF ENZYME INHIBITION | 1994年 / 8卷 / 01期
关键词
ALSOPHILA SPINULOSA HT (CYATHEACEAE); LEAVES; PHENOLIC COMPOUNDS; FLAVONOID; XANTHINE OXIDASE INHIBITORS; HEPATITIS; GOUT; TUMOR;
D O I
10.3109/14756369409040777
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diploptene(1), beta-sitosterol(2), a mixture of 6'-O-(E-P-coumaroyl)-alpha-glucopyranose and 6'-O-(E-P-coumaroyl) -beta-glucopyranose(3), a mixture of 6'-O-(E-P-caffeoyl)-alpha-glucopyranose and 6'-O-(E-P-caffeoyl)-beta-glucopyranose(4), caffeic acid(5) and astragalin(6) were isolated from an ethanolic extract of the leaves of Alsophila spinulosa Hook Tryon (Cyatheaceae). The plant has been used in folk medicine for hepatitis, gout, rheumatism and tumor and these compounds were tested for their inhibitory effect on xanthine oxidase. Caffeic acid was the most potent constituent (IC50 = 39.21 mu M; K-i = 28.2 mu M) and was an uncompetitive inhibitor of the enzyme with respect to the substrate xanthine.
引用
收藏
页码:61 / 71
页数:11
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