SYNTHESIS, ISOLATION, AND SOME CHEMISTRY OF CITRIC ACID ANHYDRIDE

被引：20

作者：

REPTA, AJ

HIGUCHI, T

机构：

[1] School of Pharmacy, University of Kansas, Lawrence, Kansas

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Aniline‐citric acid anhydride–reaction products; Citric acid anhydride–synthesis; characterization; Column chromatography–separation; Hydrolysis–dric acid anhydride; UV spectrophotometry–analysis;

D O I：

10.1002/jps.2600580915

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A crystalline anhydride of citric acid has been produced for the first time. The compound was shown to be the unsymmetrical monomolecular anhydride. Details of the preparation are presented along with some of its chemistry. The rate of hydrolysis of the anhydride was found to decrease over the range pH = 1–6. Possible uses in pharmaceutical formulations are suggested. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1110 / &

共 13 条

[1] HYDROLYSIS OF CARBOXYLIC ANHYDRIDES .2. EFFECTS OF SALTS OF STRONG ACIDS ON HYDROLYSIS OF ACETIC ANHYDRIDE [J].