NASAL ADMINISTRATION OF INSULIN USING BIOADHESIVE MICROSPHERES AS A DELIVERY SYSTEM

被引：89

作者：

FARRAJ, NF ^{[1
]}

JOHANSEN, BR ^{[1
]}

DAVIS, SS ^{[1
]}

ILLUM, L ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,SCH PHARM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 13卷 / 2-3期

关键词：

bioadhesive microspheres; insulin; lysophosphatidylcholine; nasal delivery;

D O I：

10.1016/0168-3659(90)90016-M

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of the bioadhesive microsphere system for the intranasal delivery of insulin was investigated in sheep. The effect of combining the above system with lysophosphatidylcholine, as a biological absorption enhancer, was also assessed. For comparison, insulin was also administered by the intravenous and subcutaneous routes. The plasma glucose and insulin levels were determined by a glucose oxidase method and a radioimmunoassay, respectively. The bioadhesive system produced large and significant changes in the plasma insulin and glucose levels. The relative bioavailability (± standard error of measurement) of insulin administered with the microsphere system alone was found to be 10.7% (±2.6) and that of insulin administered with the microsphere /enhancer system to be 31.5% (±6.5). © 1990.

引用

页码：253 / 261

页数：9

共 19 条

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