RESPIRATORY AND HEMATOLOGICAL ADAPTATIONS OF YOUNG AND OLDER AYMARA MEN NATIVE TO 3600M

被引:10
作者
BEALL, CM
STROHL, KP
GOTHE, B
BRITTENHAM, GM
BARRAGAN, M
VARGAS, E
机构
[1] CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED,CLEVELAND,OH 44106
[2] INST BOLIVIANO TECHNOL AGROPECUARIA,LA PAZ,BOLIVIA
关键词
D O I
10.1002/ajhb.1310040105
中图分类号
Q98 [人类学];
学科分类号
030303 ;
摘要
This paper reports the results of a study designed to test the hypothesis that an inevitable concomitant of aging at high altitudes is chronic mountain sickness resulting from excess erythrocytosis secondary to exaggerated hypoxemia caused by aging processes in the respiratory system. It compares age differences in respiratory system function in oxygenating the blood measured as percent O2 saturation of arterial hemoglobin during wakefulness and sleep and in erythrocytosis measured as hemoglobin concentration in 17 young (22-35 years) and 16 older (47-68 years) rural and urban resident Bolivian Aymara men, healthy lifelong residents of 3,500-4,000 m who were tested at 3,600 m. The results do not support the hypothesis. Older urban men are significantly more hypoxemic during wakefulness and sleep than young urban men, while there are no age differences in the degree of hypoxemia among the rural residents. However, older urban men do not have the higher hemoglobin concentration predicted by the hypothesis. Both urban and rural older men have lower hemoglobin concentration than their young counterparts, a finding not attributable to age differences in nutritional status or testosterone concentration. Despite.their relatively low hemoglobin concentration, older men have estimated arterial O2 content in the normal sea level range for young men and in this sense retain the capacity to adapt to high altitude at least through the seventh decade of life.
引用
收藏
页码:17 / 26
页数:10
相关论文
共 47 条
[1]  
ALTMAN PL, 1971, BIOL HDB RESPIRATION
[2]  
Ballew C, 1989, HUMAN POPULATION BIO, P239
[3]  
Beall C. M., 1990, HYPOXIA ADAPTATIONS, P59
[4]   REAPPRAISAL OF ANDEAN HIGH-ALTITUDE ERYTHROCYTOSIS FROM A HIMALAYAN PERSPECTIVE [J].
BEALL, CM ;
STROHL, KP ;
BRITTENHAM, GM .
SEMINARS IN RESPIRATORY MEDICINE, 1983, 5 (02) :195-201
[5]   HEMOGLOBIN CONCENTRATION OF PASTORAL NOMADS PERMANENTLY RESIDENT AT 4,850-5,450 METERS IN TIBET [J].
BEALL, CM ;
GOLDSTEIN, MC .
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 1987, 73 (04) :433-438
[6]   HEMOGLOBIN LEVELS IN A HIMALAYAN HIGH-ALTITUDE POPULATION [J].
BEALL, CM ;
REICHSMAN, AB .
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 1984, 63 (03) :301-306
[7]   VARIATION IN HEMOGLOBIN CONCENTRATION AMONG SAMPLES OF HIGH-ALTITUDE NATIVES IN THE ANDES AND THE HIMALAYAS [J].
BEALL, CM ;
BRITTENHAM, GM ;
MACUAGA, F ;
BARRAGAN, M .
AMERICAN JOURNAL OF HUMAN BIOLOGY, 1990, 2 (06) :639-651
[8]  
BEALL CM, IN PRESS ANN HUM BIO
[9]   LUNG ELASTICITY AND AIRWAY DYNAMICS IN PERUVIAN NATIVES TO HIGH-ALTITUDE [J].
BRODY, JS ;
LAHIRI, S ;
SIMPSER, M ;
MOTOYAMA, EK ;
VELASQUEZ, T .
JOURNAL OF APPLIED PHYSIOLOGY, 1977, 42 (02) :245-251
[10]  
Cameron N, 1981, PRACTICAL HUMAN BIOL, P27