THE EFFECT OF ADRENOMEDULLIN ON THE ISOLATED HEART

被引：43

作者：

PERRET, M

BROUSSARD, H

LEGROS, T

BURNS, A

CHANG, JK

SUMMER, W

HYMAN, A

LIPPTON, H

机构：

[1] LSU, SCH MED, DEPT INTERNAL MED, NEW ORLEANS, LA USA

[2] LSU, SCH MED, DEPT PHYSIOL, NEW ORLEANS, LA USA

[3] LSU, SCH MED, DEPT PHARMACOL, NEW ORLEANS, LA USA

[4] TULANE UNIV, SCH MED, DEPT SURG, NEW ORLEANS, LA 70112 USA

[5] TULANE UNIV, SCH MED, DEPT PHARMACOL, NEW ORLEANS, LA 70112 USA

[6] TULANE UNIV, SCH MED, DEPT INTERNAL MED, NEW ORLEANS, LA 70112 USA

[7] PENINSULA LABS, BELMONT, CA USA

来源：

LIFE SCIENCES | 1993年 / 53卷 / 22期

关键词：

D O I：

10.1016/0024-3205(93)90213-M

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A novel peptide found in human blood, adrenomedullin (ADM), has been shown to have systemic vasodepressor activity in the rat. However, the direct effects of ADM on cardiac function are unknown. Results of the present study demonstrate that ADM13-52 possesses marked systemic vasodepressor activity in the anesthetized rat. Although ADM13-52 modestly decreased peak systolic pressure (PSP) indicating mild negative inotropic activity, the present data suggest that bolus administration of ADM decreases systemic arterial pressure by dilating the systemic vasculature. The present data also suggest that only a portion of the ADM molecule is necessary to produce systemic vasodilation.

引用

页码：PL377 / PL379

页数：3

共 3 条

[1] MYOCARDIAL METABOLIC EFFECTS OF INVIVO HYDRALAZINE TREATMENT OF STREPTOZOTOCIN-DIABETIC RATS
BURNS, AH
BURNS, LAR
JURENKA, LU
SUMMER, WR
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (02): : H516 - H521
[2] ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA
KITAMURA, K
KANGAWA, K
KAWAMOTO, M
ICHIKI, Y
NAKAMURA, S
MATSUO, H
ETO, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) : 553 - 560
[3] NEELY JR, 1967, AM J PHYSIOL, V212, P804

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