TRYPANOSOMA-CRUZI TRANS-SIALIDASE AND CELL INVASION

被引：110

作者：

SCHENKMAN, S ^{[1
]}

EICHINGER, D ^{[1
]}

机构：

[1] NYU MED CTR, DEPT PATHOL, MICHAEL HEIDELBERGER DIV IMMUNOL, NEW YORK, NY 10016 USA

来源：

PARASITOLOGY TODAY | 1993年 / 9卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/0169-4758(93)90017-A

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Trypanosoma cruzi does not synthesize sialic acid but does contain a trans-sialidase, an enzyme capable of transferring sialic acid between host glycoconjugates and the parasite. Sialic acids are negatively charged carbohydrates attached to the terminal non-reducing end of glycoproteins and glycolipids, and their presence can dramatically influence many cell-surface recognition processes. Since sialic acids have been implicated in several ligand-receptor interactions, including the interaction of pathogenic viruses, bacteria and protozoans with their hosts, the expression of trans-sialidase and the acquisition of sialic acid by T. cruzi may be relevant to the interaction of the parasite with the host, and consequently may influence the pathobiology of Chagas disease. In this review, Sergio Schenkman and Daniel Eichinger discuss recent data about the structure and function of T. cruzi trans-sialidase. © 1993.

引用

页码：218 / 222

页数：5

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