ADJUVANT GROWTH-HORMONE THERAPY IN POOR RESPONDERS TO IN-VITRO FERTILIZATION - A PROSPECTIVE RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY

被引:76
作者
DOR, J [1 ]
SEIDMAN, DS [1 ]
AMUDAI, E [1 ]
BIDER, D [1 ]
LEVRAN, D [1 ]
MASHIACH, S [1 ]
机构
[1] TEL AVIV UNIV,SACKLER SCH MED,IL-69978 TEL AVIV,ISRAEL
关键词
FOLLICULAR FLUID; GONADOTROPINS; IGF-I; OVULATION INDUCTION;
D O I
10.1093/humrep/10.1.40
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The objective of the study was to assess the effect of growth hormone (GH) supplementation to a combined gonadotrophin-releasing hormone agonist/human menopausal gonadotrophin (GnRHa/HMG) treatment protocol on ovarian response in ''poor responders'' undergoing in-vitro fertilization (IVF). GH or a placebo were administered in a prospective randomized double-blind manner, A total of 14 poor-responder patients (oestradiol <500 pg/ml, less than three oocytes retrieved in two previous IVF cycles) were randomly allocated to a combined treatment of either GnRHa/HMG/ GH (18 IU on alternate days, total dose 72 IU) or GnRHa/ HMG placebo, No difference was found between the study and control groups in the number of HMG ampoules used, the number of follicles (>14 mm) and serum oestradiol concentrations on the day of administration of human chorionic gonadotrophin (HCG), the number of oocytes retrieved and fertilized, and the number of embryos transferred, The GH group (n = 7) did not show a better ovulatory response in the study cycles; mean +/- SD serum oestradiol on day of HCG 411 +/- 124 versus 493 +/- 291 pg/ml, aspirated oocytes 2.2 +/- 1.5 versus 1.9 +/- 2.0, Interestingly, when the above results for the placebo group were compared with their previous cycles (serum oestradiol 403 +/- 231 pg/ml; 0.4 +/- 0.5 aspirated oocytes), a non-specific effect was found, Follicular recruitment, oestradiol secretion by mature follicles and the number of oocytes retrieved in poor responders were not improved by GH supplementation.
引用
收藏
页码:40 / 43
页数:4
相关论文
共 14 条
[1]   INSULIN-LIKE GROWTH FACTOR-I (IGF-I) MAY NOT BE ESSENTIAL FOR OVARIAN FOLLICULAR DEVELOPMENT - EVIDENCE FROM IGF-I DEFICIENCY [J].
DOR, J ;
BENSHLOMO, I ;
LUNENFELD, B ;
PARIENTE, C ;
LEVRAN, D ;
KARASIK, A ;
SEPPALA, M ;
MASHIACH, S .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 74 (03) :539-542
[2]   THE PROGNOSTIC IMPORTANCE OF THE NUMBER OF OOCYTES RETRIEVED AND ESTRADIOL LEVELS IN POOR AND NORMAL RESPONDERS IN INVITRO FERTILIZATION (IVF) TREATMENT [J].
DOR, J ;
SEIDMAN, DS ;
BENSHLOMO, I ;
LEVRAN, D ;
KARASIK, A ;
MASHIACH, S .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1992, 9 (03) :228-232
[3]  
DOR J, 1984, FERTIL STERIL, V41, P530
[4]   IMMUNOREACTIVE INSULIN-LIKE GROWTH FACTOR-I IN HUMAN FOLLICULAR-FLUID [J].
GEISTHOEVEL, F ;
MORETTIROJAS, IM ;
ROJAS, FJ ;
ASCH, RH .
HUMAN REPRODUCTION, 1989, 4 (01) :35-38
[5]   GROWTH-HORMONE FACILITATES OVULATION INDUCTION BY GONADOTROPINS [J].
HOMBURG, R ;
ESHEL, A ;
ABDALLA, HI ;
JACOBS, HS .
CLINICAL ENDOCRINOLOGY, 1988, 29 (01) :113-117
[6]  
HOMBURG R, 1990, FERTIL STERIL, V53, P254
[7]   CLINICAL AND ENDOCRINOLOGIC CHANGES IN WOMEN FOLLOWING OVULATION INDUCTION USING BUSERELIN ACETATE HUMAN MENOPAUSAL GONADOTROPIN AUGMENTED WITH BIOSYNTHETIC HUMAN GROWTH-HORMONE [J].
HUGHES, SM ;
HUANG, ZH ;
MATSON, PL ;
BUCK, P ;
LIEBERMAN, BA ;
MORRIS, ID .
HUMAN REPRODUCTION, 1992, 7 (06) :770-775
[8]  
IBRAHIM ZHZ, 1991, FERTIL STERIL, V55, P2202
[9]   ANOTHER LOOK AT CO-TREATMENT WITH GROWTH-HORMONE AND HUMAN MENOPAUSAL GONADOTROPINS IN POOR OVARIAN RESPONDERS [J].
LEVY, T ;
LIMOR, R ;
VILLA, Y ;
ESHEL, A ;
ECKSTEIN, N ;
VAGMAN, I ;
LIDOR, A ;
AYALON, D .
HUMAN REPRODUCTION, 1993, 8 (06) :834-839
[10]   CO-TREATMENT WITH GROWTH-HORMONE OF SUBOPTIMAL RESPONDERS IN IVF ET [J].
OWEN, EJ ;
WEST, C ;
MASON, BA ;
JACOBS, HS .
HUMAN REPRODUCTION, 1991, 6 (04) :524-528