Controlled release of newer quinolones from biodegradable systems based on poly(lactic acid)

被引：9

作者：

Andreopoulos, AG ^{[1
]}

机构：

[1] NATL TECH UNIV ATHENS,DEPT CHEM ENGN,GR-15780 ATHENS,GREECE

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 1995年 / 10卷 / 02期

关键词：

controlled release; biodegradable; quinolones; resomer; ofloxacin; pefloxacin; ciprofloxacin;

D O I：

10.1177/088532829501000206

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The release of newer quinolones (such as pefloxacin, ofloxacin, and ciprofloxacin) from biodegradable poly(D,L lactic acid) has been investigated. The in vitro study showed that drug delivery takes place for about two months and a maximum in concentration was recorded after fifteen days. The release from poly(lactic acid) slabs seemed to give high drug doses that are adequate for the treatment of infections caused by common pathogens.

引用

页码：163 / 170

页数：8

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