IMMUNITY TO ONCHOCERCIASIS - PUTATIVE IMMUNE PERSONS PRODUCE A TH1-LIKE RESPONSE TO ONCHOCERCA-VOLVULUS

被引:114
作者
ELSON, LH
CALVOPINA, M
PAREDES, W
ARAUJO, E
BRADLEY, JE
GUDERIAN, RH
NUTMAN, TB
机构
[1] HOSP VOZANDES,INVEST CLIN,QUITO,ECUADOR
[2] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT PURE & APPL BIOL,LONDON,ENGLAND
基金
美国国家卫生研究院;
关键词
D O I
10.1093/infdis/171.3.652
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunity to Onchocerca volvulus (Ov) infection is suggested by the presence of putatively immune (PI) subjects in a region of Ecuador in which Ov is endemic. PI subjects were identified by traditional diagnostic methods combined with a polymerase chain reaction-based assay for Ov DNA in skin snips. Responses of peripheral blood mononuclear cells (PBMC) from the PI group (n = 16) were compared with those of persons with active infection (microfiladermic [MF] subjects; n = 51). PBMC of PI subjects proliferated significantly more to Ov antigen (OvAg; P < .009) than did PBMC of MF persons but less to streptolysin-O (P < .001). Cytokine analysis of PBMC culture supernatants revealed that PI subjects (n = 11) produced significantly more interferon-gamma to OvAg than did those in the MF group (n = 18; P = .018), less interleukin (IL)-5 to nonparasite antigen (P = .003) and mitogen (P = .012), and less IL-10 spontaneously (P = .016). Thus, immunity to Ov may in part be mediated by an antigen-specific Th1-type response.
引用
收藏
页码:652 / 658
页数:7
相关论文
共 37 条
[1]   DIFFERENTIAL CELLULAR-REACTIVITY TO ADULT WORM ANTIGENS OF PATIENTS WITH DIFFERENT CLINICAL FORMS OF SCHISTOSOMIASIS-MANSONI [J].
BAHIAOLIVEIRA, LMG ;
GAZZINELLI, G ;
ELOISANTOS, SM ;
CUNHAMELO, JR ;
ALVESOLIVEIRA, LF ;
SILVEIRA, AMS ;
VIANA, IRC ;
CARMO, J ;
SOUZA, A ;
CORREAOLIVEIRA, R .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1992, 86 (01) :57-61
[2]  
BOYER AE, 1991, J IMMUNOL, V146, P4001
[3]  
Boyum A., 1968, SCAND J CLIN LAB INV, V97, P7
[4]   CONTRIBUTIONS OF DIFFERENT AGE GROUPS TO TRANSMISSION OF ONCHOCERCIASIS IN A CAMEROON FOREST VILLAGE [J].
DUKE, BOL ;
MOORE, PJ .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1968, 62 (01) :22-&
[5]   IMMUNITY AFTER TREATMENT OF HUMAN SCHISTOSOMIASIS - ASSOCIATION BETWEEN IGE ANTIBODIES TO ADULT WORM ANTIGENS AND RESISTANCE TO REINFECTION [J].
DUNNE, DW ;
BUTTERWORTH, AE ;
FULFORD, AJC ;
KARIUKI, HC ;
LANGLEY, JG ;
OUMA, JH ;
CAPRON, A ;
PIERCE, RJ ;
STURROCK, RF .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (06) :1483-1494
[6]  
ELSE KJ, 1992, IMMUNOLOGY, V75, P232
[7]   IMMUNITY TO ONCHOCERCIASIS - IDENTIFICATION OF A PUTATIVELY IMMUNE POPULATION IN A HYPERENDEMIC AREA OF ECUADOR [J].
ELSON, LH ;
GUDERIAN, RH ;
ARAUJO, E ;
BRADLEY, JE ;
DAYS, A ;
NUTMAN, TB .
JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (03) :588-594
[8]  
GALLIN M, 1988, J IMMUNOL, V140, P1999
[9]  
GRENCIS RK, 1991, IMMUNOLOGY, V74, P329
[10]   HUMAN IGE, IGG4 AND RESISTANCE TO REINFECTION WITH SCHISTOSOMA-HAEMATOBIUM [J].
HAGAN, P ;
BLUMENTHAL, UJ ;
DUNN, D ;
SIMPSON, AJG ;
WILKINS, HA .
NATURE, 1991, 349 (6306) :243-245