SELECTIVE INHIBITORY ACTIONS OF SODIUM-PARA-BENZYL-4-[1-OXO-2-(4-CHLOROBENZYL)-3-PHENYL PROPYL] PHENYL PHOSPHONATE (N-0164) AND INDOMETHACIN ON BIOSYNTHESIS OF PROSTAGLANDINS AND THROMBOXANES FROM ARACHIDONIC-ACID

被引：22

作者：

EAKINS, KE

KULKARNI, PS

机构：

[1] COLUMBIA UNIV,COLL PHYS & SURG,DEPT OPHTHALMOL,NEW YORK,NY 10032

[2] COLUMBIA UNIV,COLL PHYS & SURG,DEPT PHARMACOL,NEW YORK,NY 10032

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1977年 / 60卷 / 01期

关键词：

D O I：

10.1111/j.1476-5381.1977.tb16757.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：135 / 140

页数：6

共 19 条

[1]

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[2] PROSTAGLANDIN ANTAGONISM BY SODIUM PARA-BENZYL-4-[1-OXO-2-(4-CHLOROBENZYL)-3-PHENYLPROPYL]PHENYLPHOSPHONATE (N-0164) [J].

EAKINS, KE ;

RAJADHYAKSHA, V ;

SCHROER, R .

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[3] CORONARY ARTERIAL SMOOTH-MUSCLE CONTRACTION BY A SUBSTANCE RELEASED FROM PLATELETS - EVIDENCE THAT IT IS THROMBOXANE-A2 [J].

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PAYNE, NA ;

SWEETMAN, BJ ;

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[4] PROSTAGLANDINS RELEASED BY SPLEEN [J].

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VANE, JR ;

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[5] DETECTION AND ISOLATION OF AN ENDOPEROXIDE INTERMEDIATE IN PROSTAGLANDIN BIOSYNTHESIS [J].

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SAMUELSS.B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :899-903

[6] THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

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[7]

HAMBERG M, 1976, ADV PROSTAG THROMB R, V1, P19

[8] N-0164 INHIBITS GENERATION OF THROMBOXANE-A2-LIKE ACTIVITY FROM PROSTAGLANDIN ENDOPEROXIDES BY HUMAN PLATELET MICROSOMES [J].

KULKARNI, PS ;

EAKINS, KE .

PROSTAGLANDINS, 1976, 12 (03) :465-469

[9] PARADOXICAL ENDOGENOUS SYNTHESIS OF A CORONARY DILATING SUBSTANCE FROM ARACHIDONATE [J].

KULKARNI, PS ;

ROBERTS, R ;

NEEDLEMAN, P .

PROSTAGLANDINS, 1976, 12 (03) :337-353

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

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