ADVANTAGES OF ALUMINIUM HYDROXIDE ADSORBED COMBINED DIPHTHERIA TETANUS AND PERTUSSIS VACCINES FOR IMMUNIZATION OF INFANTS

被引：86

作者：

BUTLER, NR

BURLAND, WL

VOYCE, MA

HILTON, ML

机构：

[1] University of Bristol, West Cornwall Clinical Area

[2] Clinical Research Unit, Glaxo Labotatories Ltd, Greenford

[3] Glaxo Research Ltd, Greenford

来源：

BMJ-BRITISH MEDICAL JOURNAL | 1969年 / 1卷 / 5645期

关键词：

D O I：

10.1136/bmj.1.5645.663

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three combined triple antigen vaccines were used to inoculate infants receiving primary immunization at 3 to 6 months of age. Laboratory potency and toxicity tests and clinical evaluation again showed that the mouse weight gain test is able to predict which vaccines will give reactions in children. The addition of aluminium hydroxide to the vaccine both increased potency and reduced the tendency to cause reactions. Assays on sera showed that almost all children produced agglutinins to Bordetella pertussis types 1, 2, and 3 when the vaccine contained aluminium hydroxide. © 1969, British Medical Journal Publishing Group. All rights reserved.

引用

页码：663 / +

页数：1

共 22 条

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