MODE OF ANTICOCCIDIAL ACTION OF ARPRINOCID

被引:27
作者
WANG, CC
SIMASHKEVICH, PM
STOTISH, RL
机构
[1] Merck Institute for Therapeutic Research, Rahway
关键词
D O I
10.1016/0006-2952(79)90685-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
An anticoccidial agent, arprinocid, 6-amino-9-(2-chloro-6-fluorobenzyl)purine, was found to selectively inhibit incorporation of hypoxanthine into nucleic acids of Eimeria tenella during its intracellular growth in cultured cells. Similar inhibitory effects were observed in HeLa cells, although preliminary data indicated that the drug had no apparent cytotoxicity to these cells. The drug also caused partial inhibition of hypoxanthine incorporation into the purine nucleotide pool, but stimulated formate incorporation into nucleic acids in HeLa cells. These results suggest that arprinocid does not inhibit de novo synthesis but blocks the hypoxanthine-guanine salvage pathway in HeLa cells. Similar effects exerted on coccidia could account for the mode of action of arprinocid because the parasites are believed to rely on hypoxanthine salvage as the main source of purines, whereas their hosts are capable of de novo purine synthesis. © 1979.
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页码:2241 / 2248
页数:8
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