ALTERATIONS OF SEROTONIN AND LSD RECEPTOR-BINDING FOLLOWING REPEATED ADMINISTRATION OF LSD

Repeated administration of LSD to rats (100 μg/kg every 6 hours for 4 days) resulted in significant decreases in both the KD (-17 & -23%) and Bmax (-25 %& -30%) for [3H]-5HT binding in forebrain and brainstem plus spinal cord. [3H] - LSD binding showed significant changes in Bmax values (-19%) in forebrain and brainstem plus spinal cord, while KD values were not significantly changed. Neither a single injection of LSD (100 μg/kg) nor repeated administration of brom-LSD (100 μg/kg every 6 hours for 4 days) produced any significant changes in binding. In addition, repeated LSD administration produced no significant changes in [3H] - spiroperidol binding. © 1979.