IGM-RHEUMATOID FACTORS CROSS-REACTIVE WITH IGG AND A CELL NUCLEAR ANTIGEN - APPARENT MASKING IN ORIGINAL SERUM

被引：38

作者：

JOHNSON, PM

机构：

[1] Department of Immunology, University of Liverpool, Liverpool

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb03068.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fourteen out of fifteen IgM‐rheumatoid factor (IgM‐RF) preparations isolated from high‐titred seropositive rheumatoid sera by affinity chromatography on immobilized human IgG have been shown to cross‐react with a cell nuclear antigen, as manifest by positive immunofluorescent antinuclear antibody (ANA) staining on rat liver and kidney tissue sections. The cross‐reacting ANA activity within isolated IgM‐RF preparations was inhibitabte by both human and rabbit IgG, as well as by isolated rat liver chromatin. and could be isolated from seropositive ANA‐negative sera. It would appear that this cross‐reacting ANA activity can be masked in the original seropositive serum and may often require purification of RF from serum for its manifestation. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：461 / 466

页数：6

共 17 条

[1]

AGNELLO V, 1978, ARTHRITIS RHEUM, V21, P540

[2] LYMPHOCYTES TRANSFORMED BY EPSTEIN-BARR VIRUS - INDUCTION OF NUCLEAR ANTIGEN REACTIVE WITH ANTIBODY IN RHEUMATOID-ARTHRITIS [J].