FEEDBACK-REGULATION OF PLATELET-FUNCTION BY 12S-HYDROXYEICOSATETRAENOIC ACID - INHIBITION OF ARACHIDONIC-ACID LIBERATION FROM PHOSPHOLIPIDS

被引：28

作者：

SEKIYA, F

TAKAGI, J

SASAKI, K

KAWAJIRI, K

KOBAYASHI, Y

SATO, F

SAITO, Y

机构：

[1] TOKYO INST TECHNOL,DEPT BIOL SCI,MEGURO KU,TOKYO 152,JAPAN

[2] TOKYO INST TECHNOL,DEPT BIOMOLEC ENGN,MEGURO KU,TOKYO 152,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1044卷 / 01期

关键词：

(Bovine platelet); 12S-Hydroxyicosatetraenoic acid; Arachidonic acid liberation; Platelet aggregation;

D O I：

10.1016/0005-2760(90)90232-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have proposed a mechanism that platelet aggregation is regulated by its 12-lipoxygenase product, 12 S-hydroxyeicosatetraenoic acid (12-HETE) (Sekiya, F., Takagi, J. and Saito, Y. (1989) Thrombos. Res. 56, 407-415). Inhibition of endogenous 12-HETE production by 15-HETE, a specific inhibitor of 12-lipoxygenase, accelerated aggregation of bovine platelets in response to collagen and arachidonic acid liberation from phospholipids was enhanced. Exogenously added 12-HETE suppressed collagen-induced liberation of arachidonic acid and the aggregation was also inhibited. On the other hand, 12-HETE did not interfere with thromboxane synthesis from free arachidonic acid in a cell-free system. These observations suggest that 12-HETE exerts a negative feedback to prevent excess aggregation through interference with arachidonic acid liberation from membrane phospholipids. © 1990.

引用

页码：165 / 168

页数：4

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