CLONING AND CHARACTERIZATION OF A DNA FRAGMENT THAT CONFERS SULFONAMIDE RESISTANCE IN A SEROGROUP-B, SEROTYPE-15 STRAIN OF NEISSERIA-MENINGITIDIS

被引：29

作者：

KRISTIANSEN, BE

RADSTROM, P

JENKINS, A

ASK, E

FACINELLI, B

SKOLD, O

机构：

[1] UNIV UPPSALA,CTR BIOMED,DEPT PHARMACEUT MICROBIOL,S-75123 UPPSALA,SWEDEN

[2] UNIV ANCONA,SCH MED,INST MICROBIOL,I-60131 ANCONA,ITALY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 11期

关键词：

D O I：

10.1128/AAC.34.11.2277

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

By cloning studies and complementation experiments, the sulfonamide resistance gene of a serogroup B and serotype 15 (B:15) strain of Neisseria meningitidis was localized to a 1.2-kb chromosomal SspI fragment expressing a drug-resistant dihydropteroate synthase. The fragment hybridized to DNA from both resistant and susceptible strains, suggesting that the resistance gene is a variant of the normal gene for dihydropteroate synthase.

引用

页码：2277 / 2279

页数：3

共 14 条

[1] MORTALITY IN MENINGOCOCCAL INFECTIONS
ANDERSEN, BM
[J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1978, 10 (04) : 277 - 282
[2] BIRNBOIM HC, 1979, NUCLEIC ACIDS RES, V7, P1513
[3] BOVRE K, 1980, NIPH (National Institute of Public Health) Annals (Oslo), V3, P9
[4] BOVRE K, 1983, NIPH (National Institute of Public Health) Annals (Oslo), V6, P75
[5] ANTIBIOTIC PROPHYLAXIS OF CARRIERS OF SULFADIAZINE-RESISTANT MENINGOCOCCI
DOWD, JM
BLINK, D
MILLER, CH
FRANK, PF
PIERCE, WE
[J]. JOURNAL OF INFECTIOUS DISEASES, 1966, 116 (04) : 473 - &
[6] PLASMID-MEDIATED SULFONAMIDE RESISTANCE IN NEISSERIA-MENINGITIDIS
FACINELLI, B
VARALDO, PE
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (10) : 1642 - 1643
[7] CASE FATALITY OF MENINGOCOCCAL DISEASE IN WESTERN NORWAY
HALSTENSEN, A
PEDERSEN, SHJ
HANEBERG, B
BJORVATN, B
SOLBERG, CO
[J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1987, 19 (01) : 35 - 42
[8] MENINGOCOCCIC CASES - AN ANALYSIS
HOYNE, AL
BROWN, RH
[J]. ANNALS OF INTERNAL MEDICINE, 1948, 28 (02) : 248 - 259
[9] KRISTIANSEN B-E, 1989, Tidsskrift for den Norske Laegeforening, V109, P1373
[10] AN OUTBREAK OF GROUP-B MENINGOCOCCAL DISEASE - TRACING THE CAUSATIVE STRAIN OF NEISSERIA-MENINGITIDIS BY DNA FINGERPRINTING
KRISTIANSEN, BE
SORENSEN, B
BJORVATN, B
FALK, ES
FOSSE, E
BRYN, K
FROHOLM, LO
GAUSTAD, P
BOVRE, K
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 23 (04) : 764 - 767

← 1 2 →