WUCHERERIA-BANCROFTI INFECTION IN HUMAN AND MOSQUITO POPULATIONS OF A POLYNESIAN VILLAGE 10 YEARS AFTER INTERRUPTION OF MASS CHEMOPROPHYLAXIS WITH DIETHYLCARBAMAZINE

被引:18
作者
CARTEL, JL
NGUYEN, NL
SPIEGEL, A
MOULIAPELAT, JP
PLICHART, R
MARTIN, PMV
MANUELLAN, AB
LARDEUX, F
机构
[1] Institut Territorial de Recherches Medicates Louis Malardé, Papeete, Tahiti
关键词
D O I
10.1016/0035-9203(92)90245-8
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
In 1991, a study on Wuchereria bancrofti microfilariae (mf) and infection rates was carried out in the human and mosquito populations of a Polynesian village where, 10 years before, the mf prevalence rate was 6.4% and twice-yearly mass treatment with 3 mg/kg of diethylcarbamazine (DEC) was interrupted. Venous blood samples were collected from 575 (97%) individuals aged 15 years or more, of whom 122 (21-4%) were mf positive. The mf carrier prevalence rate was 27-4% in males, significantly higher than that of 14% in females; it increased from 7-12% in the youngest age group (15-19 years) to 40-50% in the oldest (greater-than-or-equal-to 60 years) for both males and females. 387 mosquito collections were performed and 1748 female Aedes polynesiensis were dissected, of which 1176 were parous. Among the latter, 114 (9.7%) were infected with Wuchereria bancrofti larvae at L1, L2 or L3 stages. The mean number of larvae per mosquito was 2.46 (range 1-15). Of the 114 infected mosquitoes, 30 harboured L3 larvae, giving a 2.55% infective rate; the mean number of L3 larvae per mosquito was 1. 15 (range 1-2). Such findings indicate that the interruption of systematic twice-yearly mass treatment with DEC (3 mg/kg) has resulted, after 10 years, in a substantial increase of microfilarial prevalence in humans, and in high infection rates in mosquitoes.
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页码:414 / 416
页数:3
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