PHENYTOIN-INDUCED DNA-SYNTHESIS AND INOSITOL 1,4,5-TRISPHOSPHATE FORMATION IN L-929 FIBROBLASTS

被引:6
作者
DILL, RE
FARMER, GR
机构
[1] Department of Anatomy, Baylor College of Dentistry, Dallas, 75 246, Texas
来源
EXPERIENTIA | 1991年 / 47卷 / 07期
关键词
PHENYTOIN; FIBROBLASTS; INOSITOL PHOSPHATES; DNA SYNTHESIS;
D O I
10.1007/BF01958828
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Culture of L-929 fibroblasts in the presence of phenytoin (2.5-5.0-mu-g/ml) increased DNA synthesis, as indicated by increased [H-3]thymidine uptake, while a higher dose (20-mu-g/ml) inhibited DNA synthesis. In like manner, a low dose of phenytoin (5.0-mu-g/ml) was effective in increasing inositol 1,4,5-trisphosphate formation while a higher dose (10-mu-g/ml) tended to inhibit this activity. These data suggest that the formation of inositol phosphate second messengers may play a role in phenytoin-induced fibroblast proliferation and connective tissue growth.
引用
收藏
页码:728 / 730
页数:3
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