THE ACQUISITION OF PASSIVE-AVOIDANCE, ACTIVE-AVOIDANCE, AND SPATIAL NAVIGATION TASKS BY ANIMALS PRENATALLY EXPOSED TO COCAINE

被引：39

作者：

RILEY, EP ^{[1
]}

FOSS, JA ^{[1
]}

机构：

[1] SAN DIEGO STATE UNIV,DEPT PSYCHOL,SAN DIEGO,CA 92182

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 1991年 / 13卷 / 05期

关键词：

COCAINE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; AVOIDANCE CONDITIONING; SPATIAL ORIENTATION PERCEPTION;

D O I：

10.1016/0892-0362(91)90066-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pregnant Long-Evans rats were administered cocaine orally (60 mg/kg) on gestational days 14-21. One control group was administered the vehicle and another left untreated. Cocaine treatment produced some maternal lethality, and the weight gain of the surviving dams was reduced approximately 15%. Offspring of mothers treated with cocaine did not differ from those of untreated mothers in their numbers, birth weight, or growth. Weanling offspring were tested in a passive avoidance task, and adult offspring were tested for two-way active avoidance and in a spatial navigation task. Although a few animals in the cocaine group showed poor retention of passive avoidance, the group differences were not statistically significant. The adult animals showed normal performance in both the active avoidance and spatial navigation tasks.

引用

页码：559 / 564

页数：6

共 28 条

[1] EFFECT OF INUTERO COCAINE EXPOSURE ON STARTLE AND ITS MODIFICATION [J].