PRELIMINARY-STUDY OF A PREGNANOLONE EMULSION (KABI-2213) FOR IV INDUCTION OF GENERAL-ANESTHESIA

被引：35

作者：

GRAY, HS ^{[1
]}

HOLT, BL ^{[1
]}

WHITAKER, DK ^{[1
]}

EADSFORTH, P ^{[1
]}

机构：

[1] UNIV MANCHESTER,MEDEVAL CLIN INVEST UNIT,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1992年 / 68卷 / 03期

关键词：

ANESTHETICS; INTRAVENOUS; PREGNANOLONE;

D O I：

10.1093/bja/68.3.272

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Pregnanolone emulsion was administered i.v. to 13 healthy male volunteers to assess its potential as an agent for i.v. induction of general anaesthesia and to establish a pharmacokinetic profile at two doses. Each subject received 0.5 mg kg-1, 0.75 mg kg-1 and 1.0 mg kg-1 on successive occasions, the rate of administration being constant for each dose. Pregnanolone emulsion was found to produce smooth and reliable induction of general anaesthesia with cardiorespiratory effects comparable to those of other i.v. induction agents.

引用

页码：272 / 276

页数：5

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