METABOLISM OF TOLUENE IN MAN - GAS-CHROMATOGRAPHIC DETERMINATION OF ORTHO-CRESOL,META-CRESOL AND PARA-CRESOL IN URINE

被引：51

作者：

WOIWODE, W ^{[1
]}

WODARZ, R ^{[1
]}

DRYSCH, K ^{[1
]}

WEICHARDT, H ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST ARBEITS & SOZIALMED,D-7400 TUBINGEN 1,FED REP GER

来源：

ARCHIVES OF TOXICOLOGY | 1979年 / 43卷 / 02期

关键词：

Cresols; Gas-chromatography; Mass spectrometry; Metabolism; Toluene; Urine;

D O I：

10.1007/BF00333615

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Complete separation of phenol, o-, m- and p-cresol was achieved by capillary gas-chromatography. Urinary concentrations of cresols were determined quantitatively in samples from 10 male workers exposed to toluene. Besides pcresol, o- and m-cresol were found to be urinary compounds in the case of the exposed group in contrast to normal persons. This finding was proved by gas-chromatography/mass spectrometry. The difference between both groups is significant. It is concluded that besides hippuric acid o-, m- and p-cresol are metabolites of toluene. © 1979 Springer-Verlag.

引用

页码：93 / 98

页数：6

共 11 条

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