[H-3] SAXITOXINOL METABOLISM AND ELIMINATION IN THE RAT

被引：23

作者：

HINES, HB

NASEEM, SM

WANNEMACHER, RW

机构：

[1] Pathophysiology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick

来源：

TOXICON | 1993年 / 31卷 / 07期

关键词：

D O I：

10.1016/0041-0101(93)90226-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tritiated saxitoxinol was used to obtain preliminary information on saxitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxinol (18.9-muCi/kg; 3.8 mug/kg) were injected i.v. into each of six rats. Urine and fecal samples were collected up to 144 hr post-injection. Within 4 hr, 60% of injected radioactivity was excreted in urine. No radioactivity was found in feces. High performance liquid chromatography analyses of urine showed that saxitoxinol was not metabolized by the rats.

引用

页码：905 / 908

页数：4

共 7 条

[1]

ACRES J, 1978, CAN MED ASSOC J, V119, P1195

[2] FOOD POISONING [J].

MEYER, KF .

NEW ENGLAND JOURNAL OF MEDICINE, 1953, 249 (21) :843-852

[3]

MILLER T, 1989, FASEB Journal, V3, pA688

[4] SHELLFISH AND FISH POISONING RELATED TO THE TOXIC DINOFLAGELLATES [J].

SAKAMOTO, Y ;

LOCKEY, RF ;

KRZANOWSKI, JJ .

SOUTHERN MEDICAL JOURNAL, 1987, 80 (07) :866-874

[5] STRUCTURE OF SAXITOXIN IN SOLUTIONS AND STEREOCHEMISTRY OF DIHYDROSAXITOXINS [J].

SHIMIZU, Y ;

HSU, CP ;

GENENAH, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (03) :605-609

[6]

Shimizu Y., 1988, HDB NATURAL TOXINS, V3, P63

[7]

SULLIVAN JJ, 1983, J ASSOC OFF ANA CHEM, V66, P297

← 1 →