FETAL SERUM FERRITIN AND COBALAMIN IN RED-BLOOD-CELL ISOIMMUNIZATION

被引:3
作者
ABBAS, A
NICOLAIDES, K
机构
[1] Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital Medical School, London
关键词
FERRITIN; COBALAMIN; RED BLOOD CELL ISOIMMUNIZATION;
D O I
10.1159/000264247
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Fetal and maternal serum ferritin and cobalamin concentrations were examined in 40 red blood cell-isoimmunised pregnancies undergoing cordocentesis at 18-38 weeks of gestation and the values were compared to those of normal pregnancies. In the red blood cell-isoimmunised pregnancies, the fetal serum ferritin concentration was increased and the cobalamin Concentration was decreased, whereas maternal serum ferritin was decreased and cobalamin was not significantly different from normals. There was a significant association between the degree of fetal anaemia and the increase in fetal serum ferritin concentration, but not with fetal serum cobalamin. This study suggests that fetal haemolytic anaemia is associated with iron overload and cobalamin deficiency.
引用
收藏
页码:297 / 300
页数:4
相关论文
共 8 条
  • [1] Abbas A., Snijders R.J.M., Sadallah S., Nicolaides K.H., Fetal serum ferritin and cobalamin in normal pregnancy, Fetal Diagn Ther, 9, pp. 14-18, (1991)
  • [2] Nicolaides K.H., Rodeck C.H., Maternal serum anti-D concentration in the assessment of rhesus disease, Br Med J, 304, pp. 1155-1156, (1993)
  • [3] Nicolaides K.H., Thilaganathan B., Mibashan R.S., Cordocentesis in the investigation of fetal erythropoiesis, Am J Obstet Gynecol, 161, pp. 1197-1200, (1989)
  • [4] Modell B., Berdoukas V., The Clinical Approach to Thalassemia, pp. 64-66, (1984)
  • [5] Parmley R.T., Barton J.C., Conard M., Ultrastructural localization of transferin, transferin receptors and iron binding sites on human placental and duodenal microvilli, Br J Haematol, 60, pp. 81-89, (1985)
  • [6] O'Brien R.T., Iron overload: Clinical and pathologic aspects in pediatrics, Semin Hematol, 74, (1977)
  • [7] Berger H.M., Lindeman J.H.N., Van Zoeren-Grobben D., Houdkamp E., Schrijver J., Kanhai H.H., Iron overload, free radical damage, and rhesus haemolytic disease, Lancet, 335, pp. 933-936, (1990)
  • [8] Bilardo C.M., Nicolaides K.H., Campbell S., Doppler studies in red cell isoimmunization, Clin Obstet Gynecol, 32, pp. 719-727, (1989)