An experimental model for non-union in rats

被引:71
作者
Hietaniemi, K [1 ]
Peltonen, J [1 ]
Paavolainen, P [1 ]
机构
[1] JORVI HOSP,DEPT SURG,SF-02740 ESPOO,FINLAND
来源
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 1995年 / 26卷 / 10期
关键词
D O I
10.1016/0020-1383(95)00135-2
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Few studies of the biological changes which occur in impaired fracture repair and non-union have been carried out, and creating an appropriate model for advanced biochemical studies of non-union has proved to be a demanding task. This paper presents a standardized experimental model for producing non-union in rat femurs, for use in biochemical studies of non-union. A mid-diaphyseal fracture with a rotationally unstable fixation was performed in rats with a mean weight of over 330 g and mean age of over 10 weeks. Radiologically and histologically (Alcian blue and Safranin O stainings) the signs of undisturbed fracture healing were observed until 3 weeks after the fracture. Thereafter there was evidence that chondrocytic activity ceased, with no signs of formation of calcifying bridging callus. From the seventh week onwards, all elements necessary for a calcifying callus were lost; and the histological picture tended to be of scar tissue bond between the fracture ends.
引用
收藏
页码:681 / 686
页数:6
相关论文
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