PYRAZINE DIURETICS .6. (PYRAZINECARBOXAMIDO)GUANIDINES

The synthesis of a series of (pyrazinecarboxamido)guanidines by a number of methods is described. These compounds, like their N-amidinopyrazinecarboxamide analogs, cause diuresis and saluresis in rats and dogs while potassium excretion is unaffected or repressed. Cyclization of a number of these compounds produced the analogous pyrazinyltriazoles which were generally less potent than the (pyrazinecarboxamido)guanidines. © 1969, American Chemical Society. All rights reserved.