Prokaryotic and eukaryotic porins

被引：13

作者：

Schirmer, Tilman ^{[1
]}

Rosenbusch, Jurg P. ^{[1
]}

机构：

[1] Univ Basel, Bioctr, Klingelbergstr 70, CH-4056 Basel, Switzerland

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1991年 / 1卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(05)80075-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Porins form water-filled, voltage-controlled channels across bacterial outer membranes. The trimeric protein resides within the hydrophobic membrane domain with unusual stability despite its hydrophilicity. Its channels are formed by beta-barrels (one per monomer) that consist of single antiparallel pleated sheets. This motif is found over a considerable evolutionary distance. The general significance of this folding pattern in membrane proteins can only be evaluated once more high-resolution structures have been determined.

引用

页码：539 / 545

页数：7

共 66 条

[1] MUTATIONS THAT ALTER THE PORE FUNCTION OF THE OMPF PORIN OF ESCHERICHIA-COLI-K12
BENSON, SA
OCCI, JLL
SAMPSON, BA
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1988, 203 (04) : 961 - 970
[2] FORMATION OF LARGE, ION-PERMEABLE MEMBRANE CHANNELS BY MATRIX PROTEIN (PORIN) OF ESCHERICHIA-COLI
BENZ, R
JANKO, K
BOOS, W
LAUGER, P
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 511 (03) : 305 - 319
[3] BIOPHYSICAL PROPERTIES OF PORIN PORES FROM MITOCHONDRIAL OUTER-MEMBRANE OF EUKARYOTIC CELLS
BENZ, R
[J]. EXPERIENTIA, 1990, 46 (02): : 131 - 137
[4] SELECTIVITY CHANGES IN SITE-DIRECTED MUTANTS OF THE VDAC ION CHANNEL - STRUCTURAL IMPLICATIONS
BLACHLYDYSON, E
PENG, SZ
COLOMBINI, M
FORTE, M
[J]. SCIENCE, 1990, 247 (4947) : 1233 - 1236
[5] PROBING THE STRUCTURE OF THE MITOCHONDRIAL CHANNEL, VDAC, BY SITE-DIRECTED MUTAGENESIS - A PROGRESS REPORT
BLACHLYDYSON, E
PENG, SZ
COLOMBINI, M
FORTE, M
[J]. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1989, 21 (04) : 471 - 483
[6] CASCIO M, 1990, J BIOL CHEM, V265, P2358
[7] PROJECTED STRUCTURE OF THE PORE-FORMING OMPC PROTEIN FROM ESCHERICHIA-COLI OUTER-MEMBRANE
CHANG, CF
MIZUSHIMA, S
GLAESER, RM
[J]. BIOPHYSICAL JOURNAL, 1985, 47 (05) : 629 - 639
[8] MALTOSE TRANSPORT AND STARCH BINDING IN PHAGE-RESISTANT POINT MUTANTS OF MALTOPORIN - FUNCTIONAL AND TOPOLOGICAL IMPLICATIONS
CHARBIT, A
GEHRING, K
NIKAIDO, H
FERENCI, T
HOFNUNG, M
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1988, 201 (03) : 487 - 496
[9] SELECTIVITY FOR MALTOSE AND MALTODEXTRINS OF MALTOPORIN, A PORE-FORMING PROTEIN OF ESCHERICHIA-COLI OUTER-MEMBRANE
DARGENT, B
ROSENBUSCH, J
PATTUS, F
[J]. FEBS LETTERS, 1987, 220 (01) : 136 - 142
[10] PORE-FORMING PROTEINS OF BIOLOGICAL-MEMBRANES - INTRODUCTION
DIHANICH, M
[J]. EXPERIENTIA, 1990, 46 (02): : 131 - 131

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