SEPARATION OF WATER SOLUBLE EPIDERMAL PROTEINS BY MEANS OF DISC-ELECTROPHORESIS

Separation of proteins of water soluble extracts from normal and from psoriatic epidermis, as well as from psoriatic scales by means of disc electrophoresis yielded 4-5 protein bands showing greater electrophoretic mobility than does albumin. These proteins could be identified as nucleoproteins. In normal stratum corneum and callus only one protein band was observed in front of albumin. This protein seems to be identical with the fastest moving band obtained with the epidermal extracts. In extracts of psoriatic scales and psoriatic epidermis the globulin fraction of the proteinspectrum showed several nucleoproteins not found in normal epidermis and stratum corneum. Most characteristic were two adjacent bands. © 1969 Springer-Verlag.