VINYLSILANE MEDIATED STEREOSELECTIVE TOTAL SYNTHESIS OF (+/-)-GYMNOMITROL

被引:50
作者
HAN, YK [1 ]
PAQUETTE, LA [1 ]
机构
[1] OHIO STATE UNIV,EVANS CHEM LABS,COLUMBUS,OH 43210
关键词
D O I
10.1021/jo01335a032
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient and stereoselective synthesis of (i)-gymnomitrol was achieved by tandem conjugate addition-methylation of a vinylsilane reagent to 1, 5-dimethyl-2-methylenebicyclo[3.3.0]octan-3-one, followed by epoxidation, hydrolysis, cyclization, and introduction of the exocyclic methylene carbon. © 1979, American Chemical Society. All rights reserved.
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页码:3731 / 3733
页数:3
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