LIPID A MUTANTS OF VIBRIO-CHOLERAE - ISOLATION AND PARTIAL CHARACTERIZATION

被引：5

作者：

PAUL, S

SEN, AK

BANERJEE, N

CHATTERJEE, AN

DAS, J

机构：

[1] INDIAN INST CHEM BIOL,DIV BIOPHYS,CALCUTTA 700032,W BENGAL,INDIA

[2] INDIAN INST CHEM BIOL,DEPT ORGAN CHEM,CALCUTTA 700032,W BENGAL,INDIA

[3] JADAVPUR UNIV,DEPT FOOD TECH & BIOCHEM ENGN,CALCUTTA 700032,W BENGAL,INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91441-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vibriocholerae mutants resistant to common antibiotics and neutral and anionic detergents were isolated. Analysis of isolated outer membranes revealed a significant deficiency in the acylation of lipid A in the resistant strains. The content of amide-linked and ester-bound fatty acids in the lipid A of the mutant strains compared to that of the wild type was about 50-56% and 29-37% respectively. This defect was specific for lipid A as there was no change in the acylation of phospholipids. The reduction in fatty acid content of lipid A was reflected in the altered endotoxic properties in the mutant strains. © 1990.

引用

页码：116 / 122

页数：7

共 25 条

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