A NEW SCREENING METHOD FOR MELANIN BIOSYNTHESIS INHIBITORS USING STREPTOMYCES-BIKINIENSIS

被引：52

作者：

TOMITA, K

ODA, N

OHBAYASHI, M

KAMEI, H

MIYAKI, T

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 12期

关键词：

D O I：

10.7164/antibiotics.43.1601

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis NRRL B-1049 as the indicator organism has been developed. Several known compounds, including tyrosinase inhibitors, were found to inhibit melanin production of S. bikiniensis on agar plates. This screening method was applied to fermentation broths of actinomycetes and several cultures with melanin biosynthesis inhibitory activity were found.

引用

页码：1601 / 1605

页数：5

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