LIPASE-CATALYZED ENANTIOSELECTIVE ACIDOLYSIS OF CHIRAL 2-METHYLALKANOATES

被引：14

作者：

ENGEL, KH

机构：

[1] Institut für Biotechnologie, Fachgebiet Chemisch-Technische Analyse, Technische Universität Berlin, Berlin, D-1000

来源：

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY | 1992年 / 69卷 / 02期

关键词：

ACIDOLYSIS; CHIRALITY; ENANTIOSELECTIVITY; ESTERIFICATION; KINETIC RESOLUTION; LIPASE; 2-METHYLALKANOATES; TRANSESTERIFICATION;

D O I：

10.1007/BF02540565

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Lipase from Candida cylindracea catalyzes the acidolysis between racemic 2-methylalkanoates and fatty acids in heptane with a preference for the (S)-configurated esters. Velocity and enantioselectivity of the acyl transfer are strongly influenced by the structures of the initial substrates. The potential of this strategy for kinetic resolution of the enantiomers of chiral 2-methylalkanoates is demonstrated. Limitations of the procedure due to the reversible character of the reaction are discussed.

引用

页码：146 / 150

页数：5

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