A SPECIFIC SEQUENCE OF STIMULATION IS REQUIRED TO INDUCE SYNTHESIS OF THE ANTIMICROBIAL MOLECULE NITRIC-OXIDE BY MOUSE MACROPHAGES

被引：64

作者：

LORSBACH, RB

RUSSELL, SW

机构：

[1] UNIV KANSAS,MED CTR,CTR CANC,WILKINSON LAB,KANSAS CITY,KS 66160

[2] UNIV KANSAS,MED CTR,DEPT PATHOL,KANSAS CITY,KS 66160

[3] UNIV KANSAS,MED CTR,DEPT ONCOL,KANSAS CITY,KS 66160

[4] UNIV KANSAS,MED CTR,DEPT MICROBIOL MOLEC GENET & IMMUNOL,KANSAS CITY,KS 66160

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 05期

关键词：

D O I：

10.1128/IAI.60.5.2133-2135.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nitric oxide production by macrophages required either simultaneous or sequential exposure to gamma interferon and lipopolysaccharide; exposure to lipopolysaccharide followed by exposure to gamma interferon gave little response. The apparently evanescent nature of the lipopolysaccharide signal, necessitating persistent stimulation, could be essential to down-regulating nitric oxide production after bacteria are cleared in vivo.

引用

页码：2133 / 2135

页数：3

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