SYNTHESIS AND CONFIGURATION OF SOME SPIRO[INDAN-2,2'-PYRROLIDININE] AND SPIRO[PYRROLIDINE-2,2'-TETRALINE] DERIVATIVES

被引：4

作者：

STOLL, AP

PETCHER, TJ

WEBER, HP

机构：

[1] Sandoz AG, Pharma-Department, Chemische Forschung, Basel

来源：

HELVETICA CHIMICA ACTA | 1979年 / 62卷 / 04期

关键词：

D O I：

10.1002/hlca.19790620433

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis and configuration of some spiro [indan‐2,2′‐pyrrolidine] and spiro [pyrrolidine‐2,2′‐tetraline] derivatives Catalytic hydrogenation of the nitrosoindan and nitrosotetralin derivatives 8 yielded trans‐1‐hydroxy‐spiro [indan‐2,2′‐pyrrolidin]‐5′‐one (9) and trans‐1′‐hydroxy‐spiro [pyrrolidine‐2,2′‐tetralin]‐5‐one (10) respectively, whilst the corresponding cis compounds 12 and 15 were prepared via the chlorides 11 and 14. The configurations of 10 and 13 were determined by X‐Ray analysis. Copyright © 1979 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：1223 / 1230

页数：8

共 7 条

[1] INTRAMOLECULAR ACYLATION .2. THE RING CLOSURE OF SOME ALPHA-SUBSTITUTED GLUTARIC ACIDS [J].