RENAL AND EXTRARENAL SITES OF ACTION OF DIURETICS

被引：17

作者：

GIEBISCH, G

KLEINROBBENHAAR, G

KLEINROBBENHAAR, J

RATHEISER, K

UNWIN, R

机构：

[1] Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, 06510, CT

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1993年 / 7卷

关键词：

TORASEMIDE; FUROSEMIDE; RENAL CLEARANCE; MICROPUNCTURE; MICROPERFUSION; LOOP DIURETICS;

D O I：

10.1007/BF00877954

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This paper provides (a) a survey of the basic tubule transport mechanisms of sodium and potassium ions along the nephron, (b) a comparison of the overall renal effects of two diuretic agents (torasemide and furosemide), as assessed by renal clearance techniques, (c) an analysis of the tubule sites of action of torasemide evaluated by free-flow micropuncture and microperfusion techniques, and (d) a brief evaluation of some extrarenal transport effects of loop diuretics.

引用

页码：11 / 21

页数：11

共 43 条

[1]

ARONSON PS, 1989, ANNU REV PHYSIOL, V51, P419

[2]

BRAITSCH R, 1990, DIURETICS, V3, P137

[3] TRANSPORT ACTIVITY MODIFIES THICK ASCENDING LIMB DAMAGE IN THE ISOLATED PERFUSED KIDNEY [J].

BREZIS, M ;

ROSEN, S ;

SILVA, P ;

EPSTEIN, FH .

KIDNEY INTERNATIONAL, 1984, 25 (01) :65-72

[4]

BRYER J, 1990, ANNU REV MED, V41, P256

[5] SITE OF ACTION OF TORASEMIDE IN MAN [J].

CUVELIER, R ;

PELLEGRIN, P ;

LESNE, M ;

VANYPERSELEDESTRIHOU, C .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 31 :15-19

[6]

DIETL P, 1990, SEMIN NEPHROL, V10, P350

[7] CHARACTERIZATION OF K-ATPASE ACTIVITY IN DISTAL NEPHRON - STIMULATION BY POTASSIUM-DEPLETION [J].

DOUCET, A ;

MARSY, S .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (03) :F418-F423

[8]

FIELD MJ, 1984, J PHARMACOL EXP THER, V230, P62

[9]

FIELD MJ, 1989, REGULATION POTASSIUM, P139

[10]

FRIEDMAN PA, 1987, CONTEMP ISS NEPHROL, V16, P377

← 1 2 3 4 5 →