RELATIONSHIP BETWEEN PHARMACOLOGICAL PROPERTIES AND CLINICAL EFFICACY OF RUMINANT ANTHELMINTICS

被引：102

作者：

LANUSSE, CE ^{[1
]}

PRICHARD, RK ^{[1
]}

机构：

[1] MCGILL UNIV, INST PARASITOL, Ste Anne De Bellevue H9X 1C0, QUEBEC, CANADA

来源：

VETERINARY PARASITOLOGY | 1993年 / 49卷 / 2-4期

关键词：

D O I：

10.1016/0304-4017(93)90115-4

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The purpose of this review article is to establish a relationship between pharmacological properties and clinical efficacy of the most widely used broad-spectrum veterinary anthelmintics. The impact of drug pharmacokinetics/pharmacodynamics on anthelmintic efficacy and resistance is discussed. We review the clinical pharmacokinetics of the currently available anthelmintics used in livestock-imidazothiazoles, tetrahydropyrimidines, benzimidazoles/pro-benzimidazoles, salicylanilides (closantel) and avermectin-type compounds. Understanding the pharmacokinetic and metabolic behaviour of broad-spectrum anthelmintics in the host, and factors modulating that behaviour, is highly important for maximizing anthelmintic utility and efficacy.

引用

页码：123 / 158

页数：36

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