DOSE-DEPENDENT EFFECTS OF ALCOHOL ON VISUAL-EVOKED POTENTIALS

被引:24
作者
COLRAIN, IM
TAYLOR, J
MCLEAN, S
BUTTERY, R
WISE, G
MONTGOMERY, I
机构
[1] ROYAL VICTORIAN EYE & EAR HOSP,HOBART,AUSTRALIA
[2] TASMANIAN LIONS EYE DIAGNOST CTR,HOBART,AUSTRALIA
[3] UNIV TASMANIA,DEPT PSYCHOL,HOBART,TAS 7001,AUSTRALIA
[4] UNIV TASMANIA,SCH PHARM,HOBART,TAS 7001,AUSTRALIA
关键词
ALCOHOL; P3; P300; VISUAL EVOKED POTENTIAL; REACTION TIME;
D O I
10.1007/BF02244937
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of various alcohol doses on components of the visual evoked potential were investigated. Using a repeated measures, Latin square design, five alcohol dose conditions were administered to ten male subjects: 0.00 (placebo); 0.28; 0.36; 0.54 and 0.72 g/kg total body weight. EEG responses to a reversing checker board stimulus were measured in a standard oddball paradigm. In the alcohol conditions, latencies of the P1 and P2 components of the VEP were unaffected. However, reaction time, and the latencies of N2 and P3 displayed significant dose related increases with increasing blood alcohol levels. Further, RMS power of the P3 complex was reduced by higher alcohol doses, as was the N2-P3 amplitude difference at central and parietal sites. It is concluded that the latency and power of the endogenous components of the VEP are altered by alcohol, without effects being seen in earlier components.
引用
收藏
页码:383 / 388
页数:6
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