TC-99M-DTPA CLEARANCE IN PRETERM LAMBS - EFFECT OF SURFACTANT THERAPY AND VENTILATION

被引:6
作者
JEFFERIES, AL
DUNN, MS
POSSMAYER, F
TAI, KFY
机构
[1] UNIV TORONTO, WOMENS COLL HOSP, TORONTO M5S 1A1, ONTARIO, CANADA
[2] UNIV WESTERN ONTARIO, DEPT OBSTET & GYNECOL, LONDON N6A 3K7, ONTARIO, CANADA
来源
AMERICAN REVIEW OF RESPIRATORY DISEASE | 1993年 / 148卷 / 04期
关键词
D O I
10.1164/ajrccm/148.4_Pt_1.845
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Surfactant therapy and high-frequency oscillatory ventilation (HFO) may minimize damage to the pulmonary epithelium of surfactant-deficient newborns. Using pulmonary clearance of insufflated, aerosolized Tc-99m-DTPA (molecular weight 492) as an index of lung epithelial permeability, we examined the effects of 300 mg bovine lipid extract surfactant (S) administered at birth to preterm lambs ventilated by either HFO or conventional mechanical ventilation (CMV). Four groups of lambs, delivered by cesarean section at 129 to 133 days of gestation, were studied: (1) HFO + S, (2) CMV + S, (3) HFO, and (4) CMV Tc-99m-DTPA clearance was assessed at 2, 4, and 5.5 h after birth. Surfactant treatment improved oxygenation and lung pressure-volume relationships, with oxygenation best maintained by the combination of HFO + S. All groups had similar biexponential clearance curves at the three time points, however, and there was no significant difference in the mean rates of clearance (k) between the four groups at 2 h (k = 6.03 +/- 0. 60 [SEM], 7.04 +/- 1.46, 5.67 +/- 0.91, and 723 +/- 0.97 %/min for Groups 1, 2, 3, and 4, respectively), 4 h (k = 6.95 +/- 0.77, 5.60 +/- 0.51, 6.39 +/- 0.64, and 6.78 +/- 1.71 %/min), and 5.5 h (k = 7.43 +/- 0.78, 6.08 +/- 0.80, 7.86 +/- 0.90, and 7.95 +/- 0.66 %/min). These data suggest that neither surfactant nor HFO significantly alters pulmonary epithelial permeability to a small radiolabeled molecule in preterm lambs.
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收藏
页码:845 / 851
页数:7
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