SURVIVAL AFTER STEREOTAXIC BIOPSY AND IRRADIATION OF CEREBRAL NONANAPLASTIC, NONPILOCYTIC ASTROCYTOMA

被引:55
作者
LUNSFORD, LD
SOMAZA, S
KONDZIOLKA, D
FLICKINGER, JC
机构
[1] UNIV PITTSBURGH,DEPT RADIOL,PITTSBURGH,PA
[2] UNIV PITTSBURGH,DEPT RADIAT ONCOL,PITTSBURGH,PA
[3] PRESBYTERIAN UNIV HOSP,CTR SPECIALIZED NEUROSURG,PITTSBURGH,PA
关键词
ASTROCYTOMA; BRAIN LESION; RADIATION THERAPY; STEREOTAXIS;
D O I
10.3171/jns.1995.82.4.0523
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors investigated the outcome of stereotactic biopsy and radiotherapy in 35 consecutive adult patients with nonanaplastic, nonpilocytic astrocytomas who were diagnosed between 1982 and 1992. The median patient age at presentation was 32 years. All received fractionated external-beam radiation therapy (median dose 56 Gy) as the initial management strategy. Additional treatment in two patients included intracavitary irradiation with colloidal phosphorus-32. Six patients (17%) had documented tumor progression during the follow-up interval and died. Three others died of causes unrelated to their tumor. Median survival after stereotactic biopsy and irradiation was 118 months (9.8 years). Median survival from the time of onset of neurological symptoms was 148 months (12.3 years). Only three patients required delayed cytoreductive surgery. The outcome of brain astrocytomas, although improved because of earlier diagnosis and therapy, does not substantiate this tumor as having benign behavior; early recognition with neuroimaging, immediate histological diagnosis via stereotactic biopsy, and initial fractionated radiation therapy may provide the potential for longer survival for patients with low-grade astrocytomas. The majority of such surviving patients have a satisfactory quality of life, which is manifested by prolonged normal functional and employment status. The survival data reported in this prospective Phase I-II clinical trial suggest that stereotactic biopsy and radiation therapy are appropriate initial management strategies for astrocytomas.
引用
收藏
页码:523 / 529
页数:7
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