MEASURES OF EXPLAINED VARIATION FOR SURVIVAL-DATA

被引:118
作者
KORN, EL
SIMON, R
机构
[1] Department of Biomathematics, Ucla School of Medicine, Los Angeles, California
[2] Biometric Research Branch, National Cancer Institute, Bethesda, Maryland
[3] Biometric Research Branch, National Cancer Institute, Bethesda, Maryland, 20892, Executive Plaza North
关键词
D O I
10.1002/sim.4780090503
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The predictive power of a set of prognostic variables in a survival time model is a concept distinct from the statistical significance of the variables or the adequacy of the model fit. In this paper we discuss the importance of quantifying the predictive power of a prognostic model, and suggest measures of explained variation as a possible quantification. The important features of our approach are that (1) the measures are completely model‐based; (2) a specification of the time range of interest is easily incorporated; and (3) the null models used for comparison are derived as mixtures of the predicted distributions. Copyright © 1990 John Wiley & Sons, Ltd.
引用
收藏
页码:487 / 503
页数:17
相关论文
共 21 条
[1]  
Armitage P., Gehan E.A., Statistical methods for the identification and use of prognostic factors, International Journal of Cancer, 13, pp. 16-36, (1974)
[2]  
Zelen M., Importance of prognostic factors in planning therapeutic trials, Cancer Therapy, Prognostic Factors and Criteria of Response, pp. 1-6, (1975)
[3]  
Feinstein A.R., Hard science, soft data, and the challenges of choosing clinical variables in research, Clinical Pharmacology and Therapeutics, 22, pp. 485-498, (1977)
[4]  
Simon R., Importance of prognostic factors in cancer clinical trials, Cancer Treatment Reports, 68, pp. 185-192, (1984)
[5]  
Sather H.N., The use of prognostic factors in clinical trials, Cancer, 58, pp. 461-467, (1986)
[6]  
Keating M.J., Smith T.L., Gehan E.A., McCredie K.B., Bodey G.P., Freireich E.J., A prognostic factor analysis for use in development of predictive models for response in adult acute leukemia, Cancer, 50, pp. 457-465, (1982)
[7]  
Efron B., Regression and ANOVA with zero‐one data: measures of residual variations, Journal of the American Statistical Association, 73, pp. 113-121, (1978)
[8]  
Harrell F.E., The PHGLM procedure, SUGI Supplemental Library User's Guide, Version 5 Edition, pp. 437-466, (1986)
[9]  
Kent J.T., O'Quigley J., Measures of dependence for censored survival data, Biometrika, 75, pp. 525-534, (1988)
[10]  
Harrell F.E., Califf R.M., Pryor D.B., Lee K.L., Rosati R.A., Evaluating the yield of medical tests, Journal of the Medical Association, 247, pp. 2543-2546, (1982)