MECHANISM OF ACTION OF 15-METHYL-PGF2-ALPHA AS AN ABORTIFACIENT

被引：8

作者：

GREEN, K ^{[1
]}

SVANBORG, K ^{[1
]}

机构：

[1] KAROLINSKA HOSP,DEPT CHEM 2,S-10401 STOCKHOLM,SWEDEN

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 02期

关键词：

D O I：

10.1016/0090-6980(79)90048-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several hours following administration of long acting vaginal suppositories containing 3.0 mg of 15-methyl-PGF2α for interruption of second trimester pregnancies there is an up to 10-fold increase in endogenous production of PGE2 and PGF2α before abortion as reflected by gas chromatographic-mass spectrometric determination of the major plasma metabolites of PGE2 and PGF2α. The data suggest that this increased formation of endogenous prostaglandins contributes to the induced uterine activity during the latter part of the abortion process. © 1979.

引用

页码：277 / 282

页数：6

共 12 条

[1]

BERGSTROM S, 1976, PROSTAGLANDINS, V12, P17

[2]

BYGDEMAN M, 1976, OBSTET GYNECOL, V48, P221

[3]

BYGDEMAN M, 1976, ADV PROSTAG THROMB R, V2, P693

[4] DEVELOPMENT OF A VAGINAL SUPPOSITORY SUITABLE FOR SINGLE ADMINISTRATION FOR INTERRUPTION OF 2ND TRIMESTER PREGNANCY [J].